Madhumati (Genelia D’Souza) is the daughter of a politician who turns out to be a martinet at home with his attachment on power. He believes that the behavior of his daughter would influence his caste politics, so he tries to keep her from continuing her MBBS as she goes to college and moves with friends of different mentalities.
However, Madhumathi, comes to third year of medicine by maintaining her dignity and without involving in any affairs of love. Her focus is completely on studies. Once, she goes for a medical camp along with her class mates to Araku Valley. She meets Bunny (Allu Arjun) randomly in the woods nearby the medical camp. The story starts with his funny and playful encounters with Madhumathi.
Bunny comes to Hyderabad and joins in a pizza shop as a delivery boy and continues his MBA by attending evening classes.
In an incident, Madhumathi’s father thinks that his daughter is dating someone and comes to believe that its none other than Bunny. He decides to get her married to a person of his own caste who settled in a top position: Manoj Bajpai, the deputy commissioner of police.
Madhumati is more attached to her studies than marriage. She goes to Bunny and places the blame on him saying that he would be the reason for her suicide should she be forcibly married. Knowing that, Bunny plans to stop the marriage and meets the DCP. Bunny lies to him and convinces the DCP that he is in love with Madhumathi. But Bunny gets caught in his own white lie. Manoj Bajpai believes Bunny’s words and gets him married to Madhumathi in a registered marriage. He also gives his new flat for the couple to live in.
Madhumathi becomes estranged from her family and, in another series of events, ends up living with Bunny (or rather Bunny ends up living with her). Throughout their times together, mishaps and comedic events happen; Bunny ends up falling for Madhumati. Being separated from her family Madhumati has no way of paying for fees and one day expresses this to Bunny. Bunny gets into film industry as a stuntman taking high risk to his life to pay the semester fees of Madhumathi’s MBBS.