ONE NIGHT STAND starts off with a flashback that’s being narrated by Urvil (Tanuj Virwani). It is the flashback and a series of events from his past that has defined his today. The flashback starts off with a fashion show organised by his event management agency. And after completing the event successfully, Urvil and his colleagues go drinking to celebrate. It is here that his friends challenge him to speak to a rank stranger (Sunny Leone) for a few thousand rupees. An attempt to win the bet gets him introduced to the stranger who, in turn, introduces herself as Celina. What follows after that, is unlimited liquor drinking by the two of them, which ultimately lands them up in bed together.
But, the very next day, when Urvil gets up, he finds out that Celina has already left the room, without leaving any details of her whereabouts. And when Urvil comes back to his home in Pune, he is welcomed by his beautiful and dutiful wife Simran (Nyra Banerjee). Things are absolutely smooth between the couple, until one day Urvil accidentally spots Celina in the same mall wherein he has gone for shopping with his wife Simran. That very sight of Celina freshens up his ‘one night stand’ with her, which, in turn, gets translated into his desperation to meet her again. Thereafter begins his unending quest to hunt down Celina from the length and the breadth of the world. Amidst all this, Urvil gets extremely busy with his company’s big-budget event of a product launch. It is here where he gets introduced to his rich client and his family, which takes the daylights out of Urvil.